A study found that creatine supplementation during short-term resistance training enhanced some measures of muscular performance and body composition to a greater extent following the rebound phase of training, without changes in resting hormone concentrations (Volek et al., 2004).
Insulin-like Growth Factor (IGF) and Muscle Anabolism: Creatine supplementation has been shown to increase the expression of mRNA for IGF-I and IGF-II in muscle, suggesting a potential mechanism by which creatine may facilitate muscle anabolism (Deldicque et al., 2005).
No Adverse Effects on Hormonal Indices: Studies have also indicated that creatine supplementation does not adversely affect a range of hormonal indices, including those related to muscle damage, hepatic and renal function, suggesting no apparent health risk associated with creatine supplementation in healthy individuals (Robinson et al., 2000).